5-COORDINATE PLATINUM(II) COMPLEXES CONTAINING SUBSTITUTED OLEFINS - SYNTHESIS AND CYTOSTATIC ACTIVITY

被引：19

作者：

BARTOLUCCI, S

CARPINELLI, P

DEFELICE, V

GIOVANNITTI, B

DERENZI, A

机构：

[1] NAPLES UNIV,DIPARTIMENTO CHIM,VIA MEZZOCANNONE 4,I-80134 NAPLES,ITALY

[2] NAPLES UNIV,DIPARTIMENTO CHIM ORGAN & BIOL,I-80134 NAPLES,ITALY

[3] CNR,IST BIOCHIM PROT & ENZIMOL,I-80072 ARCO,ITALY

[4] UNIV MOLISE,FAC AGRARIA,I-86100 CAMPOBASSO,ITALY

来源：

INORGANICA CHIMICA ACTA | 1992年 / 197卷 / 01期

关键词：

D O I：

10.1016/S0020-1693(00)85519-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis and characterization of five-coordinate platinum(II) complexes of general formula [PtC]X(N-N)(uns)] (X=Cl, Me; N-N=bidentate nitrogen ligands; uns=substituted alkene containing carboxy or amino groups) are described. In some cases, the hindered rotation of the prochiral unsaturated ligand around the Pt-alkene bond, alone or in conjunction with a ligand environment affording a stereogenic metal centre, gives rise to a mixture of different stereoisomers. Some of the obtained complexes were tested on the neuroblastoma cell line SK-N-MC and a considerable inhibition of cellular proliferation was detected.

引用

页码：51 / 57

页数：7

共 25 条

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