5-COORDINATE PLATINUM(II) COMPLEXES CONTAINING SUBSTITUTED OLEFINS - SYNTHESIS AND CYTOSTATIC ACTIVITY

被引:19
作者
BARTOLUCCI, S
CARPINELLI, P
DEFELICE, V
GIOVANNITTI, B
DERENZI, A
机构
[1] NAPLES UNIV,DIPARTIMENTO CHIM,VIA MEZZOCANNONE 4,I-80134 NAPLES,ITALY
[2] NAPLES UNIV,DIPARTIMENTO CHIM ORGAN & BIOL,I-80134 NAPLES,ITALY
[3] CNR,IST BIOCHIM PROT & ENZIMOL,I-80072 ARCO,ITALY
[4] UNIV MOLISE,FAC AGRARIA,I-86100 CAMPOBASSO,ITALY
关键词
D O I
10.1016/S0020-1693(00)85519-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The synthesis and characterization of five-coordinate platinum(II) complexes of general formula [PtC]X(N-N)(uns)] (X=Cl, Me; N-N=bidentate nitrogen ligands; uns=substituted alkene containing carboxy or amino groups) are described. In some cases, the hindered rotation of the prochiral unsaturated ligand around the Pt-alkene bond, alone or in conjunction with a ligand environment affording a stereogenic metal centre, gives rise to a mixture of different stereoisomers. Some of the obtained complexes were tested on the neuroblastoma cell line SK-N-MC and a considerable inhibition of cellular proliferation was detected.
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页码:51 / 57
页数:7
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