ENDOTHELIALIZED MYOINTIMAL THICKENING IN THE RAT AORTA AS A RESULT OF EXTENSIVE FREEZE INJURY

被引：13

作者：

KOLPAKOV, V ^{[1
]}

REKHTER, M ^{[1
]}

BAUMAN, O ^{[1
]}

DISCIULLO, A ^{[1
]}

DINARDO, P ^{[1
]}

DROZDOV, S ^{[1
]}

POGGI, A ^{[1
]}

MIRONOV, A ^{[1
]}

机构：

[1] IST RIC FARMACOL MARIO NEGRI,VASC & TUMOR CELL BIOL LAB,CONSORZIO MARIO NEGRI SUD,I-66030 SANTA MARIA IMBAR,ITALY

来源：

ATHEROSCLEROSIS | 1993年 / 102卷 / 02期

关键词：

AORTA; ENDOTHELIUM; SMOOTH MUSCLE CELLS; REGENERATION; INTIMAL THICKENING; ARTERIOSCLEROSIS;

D O I：

10.1016/0021-9150(93)90161-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The regeneration of rat aorta intima and medial layer was examined after extensive freeze injury that caused the death of both endothelial and smooth muscle cells. After 1 month complete re-endothelialization of the denuded area was observed. In parallel, myointimal thickening was formed by the smooth muscle cells (SMC) from the uninjured edges and its thickness increased with time. The SMC of myointimal thickening were stellate in the upper part and elongated near the internal elastic lamina. No regenerative response was seen in the medial layer, consisting only of elastic and collagen fibers, and its thickness was reduced during regeneration. These results show that the regenerative response of medial SMC to extensive freeze injury proceeds in the form of intimal thickening.

引用

页码：187 / 193

页数：7

共 15 条

[1] ENDOTHELIAL-CELL INFLUENCES ON VASCULAR SMOOTH-MUSCLE PHENOTYPE [J].

CAMPBELL, JH ;

CAMPBELL, GR .

ANNUAL REVIEW OF PHYSIOLOGY, 1986, 48 :295-306

[2]

CLOWES AW, 1983, LAB INVEST, V49, P208

[3]

GERRITY RG, 1977, AM J PATHOL, V89, P313

[4] ATTACHMENT OF SMOOTH-MUSCLE CELLS TO COLLAGEN AND THEIR MIGRATION TOWARD PLATELET-DERIVED GROWTH-FACTOR [J].

GROTENDORST, GR ;

SEPPA, HEJ ;

KLEINMAN, HK ;

MARTIN, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3669-3672

[5] ELECTRON-MICROSCOPY OF INTIMAL PLAQUES FOLLOWING INDUCTION OF LARGE SUPERFICIAL MECHANICAL INJURY (TRANSVERSE INJURY) IN RABBIT AORTA [J].

KNIERIEM, HJ ;

BONDJERS, G ;

BJORKERUD, S .

VIRCHOWS ARCHIV ABTEILUNG A PATHOLOGISCHE ANATOMIE, 1973, 359 (04) :267-282

[6] NEW MODEL OF VASCULAR CELL REPAIR INVITRO [J].

KOLPAKOV, V ;

DISCIULLO, A ;

AMORE, C ;

NASUTI, M ;

IACOVIELLO, L ;

POGGI, A ;

DONATI, MB .

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 1993, 29 (02) :109-110

[7]

MALCZAK HT, 1977, AM J PATHOL, V86, P133

[8] BALLOON CATHETER INJURY TO RABBIT CAROTID-ARTERY .1. CHANGES IN SMOOTH-MUSCLE PHENOTYPE [J].

MANDERSON, JA ;

MOSSE, PRL ;

SAFSTROM, JA ;

YOUNG, SB ;

CAMPBELL, GR .

ARTERIOSCLEROSIS, 1989, 9 (03) :289-298

[9] GROWTH-RATE OF HUMAN-FIBROBLASTS IS REPRESSED BY THE CULTURE WITHIN RECONSTITUTED COLLAGEN MATRIX BUT NOT BY THE CULTURE ON THE MATRIX [J].

NISHIYAMA, T ;

TSUNENAGA, M ;

NAKAYAMA, Y ;

ADACHI, E ;

HAYASHI, T .

MATRIX, 1989, 9 (03) :193-199

[10]

REIDY MA, 1983, LAB INVEST, V49, P569

← 1 2 →