ANTIEMETIC EFFICACY OF PROPHYLACTIC ONDANSETRON IN LAPAROSCOPIC SURGERY - RANDOMIZED, DOUBLE-BLIND COMPARISON WITH METOCLOPRAMIDE

被引:75
作者
RAPHAEL, JH
NORTON, AC
机构
[1] Department of Anaesthetics, Pilgrim Hospital, Boston
关键词
PHARMACOLOGY; METOCLOPRAMIDE; ONDANSETRON; VOMITING; NAUSEA; SURGERY; GYNECOLOGICAL;
D O I
10.1093/bja/71.6.845
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
In a randomized, double-blind study, we have compared the prophylactic antiemetic efficacy of ondansetron with that of metoclopramide in 123 patients undergoing general anaesthesia for day-case gynaecological laparoscopic surgery. The patients received either iv. ondansetron 4 mg or metoclopramide 10 mg immediately before a standard anaesthetic. The number of patients with no nausea or vomiting in the ondansteron group was 50 (82%) compared with 29 (47%) in the metoclopramide group (P < 0.001). In those patients with a previous history of postoperative nausea and vomiting, nausea was less severe in those receiving ondansetron compared with those receiving metoclopramide (P < 0.05). We conclude that preoperative prophylactic administration of i. v. ondansetron was superior to metoclopramide in preventing nausea and vomiting after general anaesthesia for day- case gynaecological laparoscopic surgery.
引用
收藏
页码:845 / 848
页数:4
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