THE NICHOLAS REACTION OF INDOLES - PROPARGYLATION OF INDOLES WITH (PROPARGYL)DICOBALT HEXACARBONYL CATIONS

被引：18

作者：

NAKAGAWA, M

MA, J

HINO, T

机构：

[1] Faculty of Pharmaceutical Sciences, Chiba University, Chiba, 260

来源：

HETEROCYCLES | 1990年 / 30卷 / 01期

关键词：

D O I：

10.3987/COM-89-S21

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indole reacted with (propargyl alcohol)Co2(CO)6 complex 1 to give 3-(1, 1-dimethylpropargyl)indole 3, whereas N′-methoxycarbonyltryptamine 7 gave the corresponding N-substituted derivative 11. The reaction of 7 with (propargyl acetate)Co2(CO)6 complex 23 provided 3a-(1,1-dimethylpropargyl)hexahydropyrroloindole cobalt complex 9. Oxidative demetalation of 3, 11, and 9 with Fe(NO3)3 gave 5, 13, and 27, respectively. Hydrogenation of 5 afforded the corresponding 3-(1,1-dimethylallyl)indole 6. © 1990.

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页码：451 / 462

页数：12

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