MODIFIED TAXOLS .2. OXIDATION-PRODUCTS OF TAXOL

被引：57

作者：

MAGRI, NF ^{[1
]}

KINGSTON, DGI ^{[1
]}

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV, DEPT CHEM, BLACKSBURG, VA 24061 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1986年 / 51卷 / 06期

关键词：

D O I：

10.1021/jo00356a006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of taxol (1) or substituted taxols with Jones'' reagent under appropriate conditions yielded 7-oxotaxol (6), 2'',7-dioxotaxol (9), or 2''-oxo-7-acetyltaxol (12). Treatment of 7-oxotaxol with DBU or silica gel yielded a D-secotaxol derivative 14. Hydrogenation of the 2''-acetate derivative of 14 yielded the unstable diketone 16, while hydrogenation of 14 itself followed by workup in methanol gave the lactone 17.

引用

页码：797 / 802

页数：6

共 41 条

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