INTERACTION OF ANGIOTENSIN-II AND ATRIAL-NATRIURETIC-PEPTIDE IN THE HUMAN-FETOPLACENTAL-UNIT

被引：26

作者：

MCQUEEN, J ^{[1
]}

JARDINE, A ^{[1
]}

KINGDOM, J ^{[1
]}

TEMPLETON, A ^{[1
]}

WHITTLE, MJ ^{[1
]}

CONNELL, JMC ^{[1
]}

机构：

[1] UNIV GLASGOW,WESTERN INFIRM,SCH MRC,BLOOD PRESSURE UNIT,GLASGOW G11 6NT,SCOTLAND

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 08期

关键词：

Angiotensin; Atrial natriuretic peptide; Placenta; Receptor;

D O I：

10.1093/ajh/3.8.641

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We have identified two classes of membrane receptor for atrial natriuretic peptide (KD(dissociation constant) 0.2, 70.1 nmol/L) and angiotensin II (KD1.7 nmol/L, 15.2 nmol/L) in human fetoplacental vasculature. In addition, in the isolated perfused placenta atrial natriuretic peptide inhibited the vasoconstrictor action of angiotensin II. These findings suggest that atrial natriuretic factor may regulate fetoplacental blood flow. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：641 / 644

页数：4

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