GENOTOXICITY STUDIES WITH THE UNSTABLE ZESTE-WHITE (UZ) SYSTEM OF DROSOPHILA-MELANOGASTER - RESULTS WITH 10 CARCINOGENIC COMPOUNDS

被引：22

作者：

BATISTEALENTORN, M ^{[1
]}

XAMENA, N ^{[1
]}

CREUS, A ^{[1
]}

MARCOS, R ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA, FAC CIENCIES, DEPT GENET & MICROBIOL, E-08193 BARCELONA, SPAIN

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1991年 / 18卷 / 02期

关键词：

CARCINOGENS; GENOTOXIC EVALUATION; SOMATIC MUTATION;

D O I：

10.1002/em.2850180207

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

To increase the number of chemicals tested using the zeste-white (UZ) somatic mutation assay, ten selected carcinogens (acetamide, acrylamide, benzo(alpha)pyrene, cyclophosphamide, diethylstilbestrol, 4-nitroquinoline N-oxide, propyleneimine, safrole, thiourea, and o-toluidine) have been evaluated in this assay. Our results show that all the compounds tested produce significant increases in the eye spot frequency at, at least, one of the concentrations assayed, indicating that the zeste-white assay appears to be highly sensitive to these carcinogenic compounds. That is in agreement with data previously reported by other authors.

引用

页码：120 / 125

页数：6

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