IMMUNOPHENOTYPIC FEATURES OF CHILDHOOD AND ADULT ACUTE LYMPHOBLASTIC-LEUKEMIA (ALL) - EXPERIENCE OF THE GERMAN MULTICENTER TRIALS ALL-BFM AND GMALL

被引：41

作者：

LUDWIG, WD

REITER, A

LOFFLER, H

GOKBUGET

HOELZER, D

RIEHM, H

THIEL, E

机构：

[1] Department of Medical Oncology, Applied Molecular Biology, Robert Rössle Clinic, Free University of Berlin

[2] Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover

[3] Department of Internal Medicine II, University of Kiel

[4] Department of Hematology and Oncology, University of Frankfurt

[5] Department of Hematology and Oncology, Klinikum Steglitz, Free University of Berlin

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 13卷

关键词：

ALL; IMMUNOPHENOTYPING;

D O I：

10.3109/10428199409052679

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunophenotyping prospectively performed in about 2800 children and adults within the framework of the German multicentre ALL trials revealed marked differences in frequency distribution of immunologic subgroups with a higher incidence of immature B-cell precursor and pre-T/T phenotypic features in adults. Detailed immunophenotypic characterization by applying monoclonal antibodies to lymphoid- and myeloid-associated antigens as well as non-lineage-restricted molecules underlined the diagnostic value of pan-B and pan-T antigens that were expressed in virtually all cases of B-cell precursor (CD19, CD24) or T-cell ALL (cytoplasmic CD3, CD7) for lineage affiliation of leukemic blasts. About 10% of children and 20% of adults disclosed simultaneous expression of lymphoid markers and at least one myeloid-lineage-associated antigen. Our data confirm that immunophenotyping in ALL provides a solid basis for a biologically oriented and reliable classification of this heterogeneous disease.

引用

页码：71 / 76

页数：6

共 38 条

[1]

Janossy G., Coustain-Smith E., Campana D., The reliability of cytoplasmic CD3 and CD22 antigen expression in the immunodiagnosis of acute leukemia: A study of 500 cases, Leukemia, 3, pp. 170-181, (1989)

[2]

Campana D., Hansen-Hagge T.E., Matutes E., Phenotypic, genotypic, cytochemical and ultrastructural characterization of acute undifferentiated leukemia, Leukemia, 4, pp. 620-624, (1990)

[3]

Foon K.A., Todd R.F., immunologic classification of leukemia and lymphoma, Blood., 68, pp. 1-31, (1986)

[4]

Greaves M.F., Differentiation-linked leukemogenesis in lymphocytes, Science, 234, pp. 697-704, (1986)

[5]

Bennett J.M., Catovsky D., Daniel M.T., Criteria for the diagnosis of acute leukemia of megakaryocytic lineage (M7), Annals of Internal Medicine, 103, pp. 460-462, (1985)

[6]

Bennett J.M., Catovsky D., Daniel M.T., Proposal for the recognition of minimally differentiated acute myeloid leukaemias (AML-MO), British Journal of Haematology, 78, pp. 325-329, (1991)

[7]

Campana D., Coustan-Smith E., Behm F.G., The definition of remission in acute leukemia with immunological techniques, Bone Marrow Transplantation, 8, pp. 429-437, (1991)

[8]

van Dongen J.J.M., Breit T.M., Adriaansen H.J., Detection of minimal residual disease in acute leukemia by immunological marker analysis and polymerase chain reaction, Leukemia, 6, Suppl 1, pp. 47-59, (1992)

[9]

Borowitz M.J., Immunologic markers in childhood acute lymphoblastic leukemia, Hematology/Oncology Clinics of North America, 4, pp. 743-765, (1990)

[10]

Pui C.H., Crist W.M., Look A.T., Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia, Blood, 76, pp. 1449-1463, (1990)

← 1 2 3 4 →