RADIATION HYPERSENSITIVITY OF LEC STRAIN RATS CONTROLLED BY A SINGLE AUTOSOMAL RECESSIVE GENE

被引：32

作者：

HAYASHI, M

OKUI, T

ENDOH, D

SATO, F

KASAI, N

NAMIOKA, S

机构：

[1] HOKKAIDO UNIV,FAC VET MED,INST PUBL HLTH,SAPPORO,HOKKAIDO 060,JAPAN

[2] HOKKAIDO UNIV,INST ANIM EXPERIMENTAT,SAPPORO,HOKKAIDO 060,JAPAN

来源：

MUTATION RESEARCH | 1994年 / 314卷 / 02期

关键词：

LEC STRAIN RATS; HYPERSENSITIVITY TO WHOLE-BODY IRRADIATION; AUTOSOMAL RECESSIVE GENE; DNA DOUBLE-STRAND BREAK REPAIR;

D O I：

10.1016/0921-8777(94)90077-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

LEC strain rats (LEC rats), which are known to develop hereditarily spontaneous fulminant hepatitis 4-5 months after birth, were highly sensitive to whole-body X-irradiation when compared to WKAH strain rats. The radiosensitivity of F1 hybrids of LEC and WKAH rats was similar to that of WKAH rats and significantly lower than that of LEC rats. Segregation data of backcross hybrids (F1 x LEC and LEC x F1) suggested that the hypersensitivity of LEC rats to whole-body irradiation is controlled by a single autosomal recessive gene. The radiosensitivity of fibroblasts from LEC rats was higher than that of fibroblasts from WKAH rats. The repair process of DNA double-strand breaks in LEC cells was slower than that in WKAH cells. LEC rats could provide a useful animal model to assist in understanding the mechanism of radiation-induced DNA damage and repair.

引用

页码：135 / 142

页数：8

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