EVIDENCE FOR THE ABILITY OF CENTRAL 5-HT1A RECEPTORS TO MODULATE THE VAGAL BRADYCARDIA INDUCED BY STIMULATING THE UPPER AIRWAYS OF ANESTHETIZED RABBITS WITH SMOKE

被引：21

作者：

FUTURONETO, HA

PIRES, JGP

GILBEY, MP

RAMAGE, AG

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT ACAD PHARMACOL,LONDON NW3 2PF,ENGLAND

[2] ROYAL FREE HOSP,SCH MED,DEPT PHYSIOL,LONDON NW3 2PF,ENGLAND

[3] UNIV FED ESPIRITO SANTO,DEPT CIENCIAS FISIOL,BR-29001 VITORIA,ES,BRAZIL

来源：

BRAIN RESEARCH | 1993年 / 629卷 / 02期

基金：

英国惠康基金;

关键词：

SEROTONIN 5-HT1A RECEPTOR; 8-HYDROXY-DPAT; BUSPIRONE; CARDIAC VAGAL MOTONEURON; UPPER AIRWAY; SMOKE; ANESTHETIZED RABBIT;

D O I：

10.1016/0006-8993(93)91345-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cigarette smoke passed through the nasal cavity of atenolol pre-treated anesthetized spontaneously breathing rabbits caused a bradycardia which was significantly modified by intracisternal application of the 5-HT1A receptor ligands 8-OH-DPAT (50 mu g.kg(-1)) and buspirone (200 mu g.kg(-1)). 8-OH-DPAT attenuated while buspirone potentiated the bradycardia. These results support the view that 5-HT1A receptors play an important role in modulating the excitability of cardiac vagal motoneurones.

引用

页码：349 / 354

页数：6

共 27 条

[1] EVIDENCE THAT CENTRAL 5-HT1A-RECEPTORS PLAY A ROLE IN THE VONBEZOLD-JARISCH REFLEX IN THE RAT [J].