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DRUG-INDUCED ACUTE-PANCREATITIS - FURTHER CRITICISM

被引：48
作者：
FRICK, TW
SPEISER, DE
BIMMLER, D
LARGIADER, F
机构：
[1] Department of Surgery and Pathology, University Hospital, Zürich
来源：
DIGESTIVE DISEASES | 1993年 / 11卷 / 02期
关键词：
ACUTE PANCREATITIS; CHEMICALLY INDUCED PANCREATITIS; DRUG-INDUCED PANCREATITIS; ETIOLOGY OF PANCREATITIS;
D O I：
10.1159/000171405
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
A comprehensive literature search was performed to collect all available data on drug-induced pancreatitis. Strong evidence for an association with acute pancreatitis has been described for anticholinesterases, calcium 2',3'-dideoxyinosine, estrogen, L-asparaginase, salicylates, thiazide-diuretics, valproic acid, and vinca alkaloids. Weak evidence has been found for antituberculous agents, azathioprine, biguanides, cisplatinum, cyclosporine A, H-2-blocking agents, loop diuretics, 6-mercaptopurine, metronidazole, pentamidine, steroids, sulfonamides, sulindac and tetracycline. Many cases were associated with underlying conditions known to induce acute pancreatitis themselves. It is concluded that for none of the drugs studied the available data are consistent enough to support a definite association with acute pancreatitis. Nevertheless, the data suggest that drugs may be a trigger or a cofactor in inducing pancreatitis.
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页码：113 / 132
页数：20
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