COMPARISON OF NITRENDIPINE AND CILAZAPRIL IN PATIENTS WITH HYPERTENSION AND NON-INSULIN-DEPENDENT DIABETES-MELLITUS

被引：12

作者：

GIUGLIANO, D ^{[1
]}

DEROSA, N ^{[1
]}

MARFELLA, R ^{[1
]}

DIMARO, G ^{[1
]}

CACCIAPUOTI, F ^{[1
]}

QUATRARO, A ^{[1
]}

ACAMPORA, R ^{[1
]}

DONOFRIO, F ^{[1
]}

机构：

[1] UNIV NAPLES 2,FAC MED,DEPT GERIATR & METAB DIS,NAPLES,ITALY

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 11期

关键词：

HYPERTENSION; NON-INSULIN-DEPENDENT DIABETES-MELLITUS; NITRENDIPINE; CILAZAPRIL; GLUCOSE METABOLISM;

D O I：

10.1093/ajh/6.11.927

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The metabolic and cardiovascular effects of nitrendipine and cilazapril in patients who have elevated blood pressure and non-insulin-dependent diabetes mellitus (NIDDM) were compared. After at least 6 weeks of a washout period, 20 NIDDM patients who had diastolic blood pressure in the range of 90-105 mm Hg received a single-blind placebo for 4 weeks and then were randomized to receive 20 mg nitrendipine once daily and 5 mg cilazapril once daily each for 12 weeks according to a crossover, double-blind procedure. Nitrendipine and cilazapril reduced diastolic blood pressure levels 12% and 13%, left ventricular mass index (LVMI) levels 13% and 12%, and raised whole glucose disposal levels 18% and 19.5%, respectively. Only nitrendipine reduced glucose-stimulated insulin levels. Nitrendipine is as effective as cilazapril in lowering diastolic blood pressure and LVMI levels and in increasing glucose disposal levels in these patients.

引用

页码：927 / 932

页数：6

共 29 条

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