REGIONAL CHANGES IN EXPRESSION OF NCAM, GFAP, AND S100 IN AGING RAT-BRAIN

被引：53

作者：

LINNEMANN, D ^{[1
]}

SKARSFELT, T ^{[1
]}

机构：

[1] H LUNDBECK & CO AS, PHARMACOL RES, DK-2500 VALBY, DENMARK

来源：

NEUROBIOLOGY OF AGING | 1994年 / 15卷 / 05期

关键词：

NCAM; GFAP; S100; AGING RAT BRAIN;

D O I：

10.1016/0197-4580(94)00060-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In aging brain degenerative processes occur. However, the aging brain still have regenerative capacity although diminished compared to young rats. The neural cell adhesion molecule (NCAM) may be involved in neuroplasticity during regenerative events. In this study, the polypeptide composition and amount of NCAM was determined in regions of brain from young, mature and old rats. During adult life, the amount of NCAM decreased in several brain regions whereas in aged rats, NCAM was enhanced in all brain regions examined. The amount of the glial fibrillary acidic protein (GFAP) increased during aging in all brain regions reflecting general gliosis in the aged rat brain. The amount of the neuro- and gliotrophic protein S100 increased from young adult to mature age in all brain regions investigated followed by a decrease during old age. Aged rats were tested in a Morris water maze and a group of rats (20%) with learning impairment was defined. However, no differences in amount of NCAM, GFAP, or S100 were observed between aged rats with and without spatial learning impairment.

引用

页码：651 / 655

页数：5

共 40 条

[1] MOUSE MONOCLONAL-ANTIBODIES REACTING WITH HUMAN-BRAIN GLIAL FIBRILLARY ACIDIC PROTEIN [J].

ALBRECHTSEN, M ;

VONGERSTENBERG, AC ;

BOCK, E .

JOURNAL OF NEUROCHEMISTRY, 1984, 42 (01) :86-93

[2] ENZYME-LINKED IMMUNOSORBENT-ASSAY FOR THE HUMAN GLIAL FIBRILLARY ACIDIC PROTEIN USING A MOUSE MONOCLONAL-ANTIBODY [J].

ALBRECHTSEN, M ;

MASSARO, A ;

BOCK, E .

JOURNAL OF NEUROCHEMISTRY, 1985, 44 (02) :560-566

[3] DEVELOPMENTAL EXPRESSION OF NEURAL CELL-ADHESION MOLECULES OF OLIGODENDROCYTES INVIVO AND IN CULTURE [J].

BHAT, S ;

SILBERBERG, DH .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (06) :1830-1838

[4]

BJORKLUND H, 1985, EXP BRAIN RES, V58, P163

[5] THE USE OF THE MORRIS WATER MAZE IN THE STUDY OF MEMORY AND LEARNING [J].

BRANDEIS, R ;

BRANDYS, Y ;

YEHUDA, S .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1989, 48 (1-2) :29-69

[6] SYNAPSE FORMATION OCCURS IN ASSOCIATION WITH THE INDUCTION OF LONG-TERM POTENTIATION IN 2-YEAR-OLD RAT HIPPOCAMPUS INVITRO [J].

CHANG, FLF ;

ISAACS, KR ;

GREENOUGH, WT .

NEUROBIOLOGY OF AGING, 1991, 12 (05) :517-522

[7] COMPENSATORY SYNAPSE GROWTH IN AGED ANIMALS AFTER NEURONAL DEATH [J].

COTMAN, CW ;

SCHEFF, SW .

MECHANISMS OF AGEING AND DEVELOPMENT, 1979, 9 (1-2) :103-117

[8] GENERAL AND DRAMATIC GLIAL REACTION IN ALZHEIMER BRAINS [J].

DELACOURTE, A .

NEUROLOGY, 1990, 40 (01) :33-37

[9] A THRESHOLD EFFECT OF THE MAJOR ISOFORMS OF NCAM ON NEURITE OUTGROWTH [J].

DOHERTY, P ;

FRUNS, M ;

SEATON, P ;

DICKSON, G ;

BARTON, CH ;

SEARS, TA ;

WALSH, FS .

NATURE, 1990, 343 (6257) :464-466

[10] INTRAVENTRICULAR INFUSIONS OF ANTINEURAL CELL-ADHESION MOLECULES IN A DISCRETE POSTTRAINING PERIOD IMPAIR CONSOLIDATION OF A PASSIVE-AVOIDANCE RESPONSE IN THE RAT [J].

DOYLE, E ;

NOLAN, PM ;

BELL, R ;

REGAN, CM .

JOURNAL OF NEUROCHEMISTRY, 1992, 59 (04) :1570-1573

← 1 2 3 4 →