EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA 1-4 IN THE CHICK LIMB BUD MESENCHYMAL CELLS - REGULATION BY 1,25-DIHYDROXYVITAMIN-D-3

被引：6

作者：

DELRIOTSONIS, K

TSONIS, PA

机构：

[1] Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 204卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2556

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When mesenchymal cells from the early chick limb bud (stage 23-24) are plated at high cell density they spontaneously undergo chondrogenesis, implicating extensive cell-to-cell interactions. In the past it has been shown that TGF-beta or 1,25 dihydroxyvitamin D-3 influences this process. In the present study we investigated the expression of TGF-beta isoforms in the mesenchymal cells after treatment with 1,25-dihydroxyvitamin D-3. We found that TGF-beta 2 was down-regulated due to the treatment. The size of the transcripts was the expected as described for sternum cartilage cells but with differential use preference. (C) 1994 Academic Press, Inc.

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收藏

页码：975 / 982

页数：8

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