INHIBITION BY SERUM COMPONENTS OF THE EXPRESSION OF LIPOPROTEIN-LIPASE GENE UPON STIMULATION BY GROWTH-HORMONE

被引：11

作者：

PRADINESFIGUERES, A ^{[1
]}

BARCELLINICOUGET, S ^{[1
]}

DANI, C ^{[1
]}

BAUDOIN, C ^{[1
]}

AILHAUD, G ^{[1
]}

机构：

[1] UNIV NICE SOPHIA ANTIPOLIS,FAC SCI,CTR BIOCHIM,CNRS,UPR 7300,PARC VALROSE,F-06034 NICE,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90982-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growth hormone regulates in a positive way the expression of the lipoprotein lipase gene at a transcriptional level in preadipocyte Ob1771 cells. Inhibition by serum components of this expression was investigated upon stimulation by growth hormone. Low-molecular weight, lipid-soluble components (a serum lipid extract, corticosteroïds and oleic acid) and high-molecular weight, hydrophilic components (TGF-β and those present in delipidated serum) were inhibitory. Inhibition of the expression of LPL mRNAs and that of LPL activity were parallel. It is concluded that the regulation of the expression of LPL gene occurs likely at a transcriptional level and that a balance between multiple effectors present in serum are active in an opposite manner. © 1990.

引用

页码：1118 / 1125

页数：8

共 19 条

[1] COUPLING OF GROWTH ARREST AND EXPRESSION OF EARLY MARKERS DURING ADIPOSE CONVERSION OF PREADIPOCYTE CELL-LINES [J].