CHANGES IN THE TRANSMURAL DISTRIBUTION OF ANTIOXIDANT ENZYME-ACTIVITIES ACROSS THE LEFT-VENTRICLE HEART WALL FROM RATS FED AD-LIBITUM OR FOOD-RESTRICTED DURING GROWTH AND AGING

被引：4

作者：

SIMONETTI, I ^{[1
]}

DETATA, V ^{[1
]}

DELROSO, A ^{[1
]}

GORI, Z ^{[1
]}

BERGAMINI, E ^{[1
]}

机构：

[1] UNIV PISA,CTR INTERDIPARTIMENTALE RIC INVECCHIAMENTO,SEZ PATOL,I-56100 PISA,ITALY

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1990年 / 10卷 / 02期

关键词：

D O I：

10.1016/0167-4943(90)90016-Y

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Data on Vulnerability to injury and on the larger age-related accumulation of lipofuscin in the subendocardial myocardium prompted us to investigate the changes in the levels and in the transmural distribution of catalase (C), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities across the left ventricle heart wall of rats fed ad libitum a standard diet or submitted to intermittent feeding during growth and aging. Enzyme activities were assayed by standard techniques on subepicardial, midmyocardial or subendo- cardial tissue obtained by cutting the heart wall into 100-αm-thick sections at the cryostat. The levels of GSH-Px and of C (but not of SOD) activity increased with age and reached their highest values in the subendocardial region by adulthood or senescence, respectively. No effect was observed of intermittent feeding on age-related changes in enzyme levels and transmural distribution. © 1990.

引用

页码：163 / 171

页数：9

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