NEUROSPORA-CRASSA CDNA CLONES CODING FOR A NEW MEMBER OF THE RAS PROTEIN FAMILY

被引：18

作者：

ALTSCHULER, DL

MURO, A

SCHIJMAN, A

ALMONACID, FB

TORRES, HN

机构：

[1] CONSEJO NACL INVEST CIENT & TECN, INST INVEST & INGN GENET & BIOL MOLEC, OBLIGADO 2490, RA-1428 BUENOS AIRES, ARGENTINA

[2] FAC CIENCIAS EXACT & NAT, RA-1428 BUENOS AIRES, ARGENTINA

来源：

FEBS LETTERS | 1990年 / 273卷 / 1-2期

关键词：

cDNA; Neurospora crassa; ras-sequence;

D O I：

10.1016/0014-5793(90)81061-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new member of the ras gene family was characterized from Neurospora crassa cDNA libraries. The clone designated NC-ras codes for a polypeptide containing 213 amino acids (Mr 24000). This polypeptide is 84% homologous to the H-ras-1 domain comprising the first 80 amino acids and 60% homologous to the next 84 residues. The NC-ras polypeptide contains all the well-known sequences involved in the interaction with GTP/GDP, the recognition of the Y13-259 neutralizing antibody, the 'effector site' for interaction with GAP proteins, and the CAAX acylation motif in the COOH-terminal. © 1990.

引用

页码：103 / 106

页数：4

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