PLASMA TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) LEVELS IN PATIENTS WITH BURNS

被引：71

作者：

ENDO, S

INADA, K

YAMADA, Y

KASAI, T

TAKAKUWA, T

NAKAE, H

KIKUCHI, M

HOSHI, S

SUZUKI, M

YAMASHITA, H

YOSHIDA, M

机构：

[1] Critical Care and Emergency Center, Iwate Medical University, Morioka, Uchimaru

[2] Department of Bacteriology, School of Medicine, Iwate Medical University, Morioka, Uchimaru

来源：

BURNS | 1993年 / 19卷 / 02期

关键词：

D O I：

10.1016/0305-4179(93)90033-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Levels of plasma tumour necrosis factor-alpha (TNF-alpha) were determined consecutively in 42 patients with burns > 20 per cent of the total body surface area using an enzyme-linked immunosorbent assay. In the early period after injury (including the period of burn shock), 24 patients had detectable TNF-alpha levels in their plasma. However, the plasma TNF-alpha levels at the time of admission were very low and did wt correlate with the extent of the burn or the prognosis. In contrast, the maximum plasma TNF-alpha level over the whole clinical course was significantly correlated with the area of the burn and the prognosis. No correlation was found between the plasma TNF-alpha and plasma endotoxin levels. TNF-alpha may be produced locally in infected burns and monitoring of plasma TNF-alpha levels may be a useful prognostic indicator for burns patients.

引用

页码：124 / 127

页数：4

共 16 条

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