SYNTHESIS AND CHARACTERIZATION OF POLYMERIC, ANIONIC THIOSALICYLATO-AG(I) COMPLEXES WITH ANTIMICROBIAL ACTIVITIES

被引：64

作者：

NOMIYA, K ^{[1
]}

KONDOH, Y ^{[1
]}

ONOUE, K ^{[1
]}

KASUGA, NC ^{[1
]}

NAGANO, H ^{[1
]}

ODA, M ^{[1
]}

SUDOH, T ^{[1
]}

SAKUMA, S ^{[1
]}

机构：

[1] MEIJI MILK PROD CO LTD,MEIJI CELL TECHNOL CTR,KANAGAWA,JAPAN

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1995年 / 58卷 / 04期

关键词：

D O I：

10.1016/0162-0134(94)00059-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thiosalicylic acid ligand (H(2)TSA = o-HS(C6H4)COOH) forms two types of anionic, light- and thermally stable Ag(I) complexes with remarkable antimicrobial activities for bacteria, yeast, and mold; one is a yellow, water-soluble complex 1 and the other an orange, water-insoluble complex 2, either of which can be converted to the other, and both of which do to not crystallize. Both are complexes with composition of metal:TSA(2-) ligand = 1:1. The complex 2 is probably polymeric, whereas the complex 1 is an oligomer with a formula of {Na[Ag(TSA(2-)). H2O]}(n)(n = 12 - 14; MW = 3600 - 4200). Both complexes have been characterized with complete elemental analyses, TG/DTA, FT-IR, and ESCA spectra in the solid state, and complex 1 as well as with molecular weight measurement in aqueous solution, and with Ag-109 and 2D NMR(H-1-H-1 COSY,H-1-C-13 COSY, and HMBC) measurements in aqueous solution.

引用

页码：255 / 267

页数：13

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