SHORT AND EFFICIENT SYNTHESIS OF (R)-4-HYDROXY-4-METHYL CYCLOHEXENONE

被引：15

作者：

BUENO, AB

CARRENO, MC

RUANO, JLG

FISCHER, J

机构：

[1] UNIV AUTONOMA MADRID,DEPT QUIM ORGAN CI,E-28049 MADRID,SPAIN

[2] UNIV STRASBOURG 1,CRISTALLOCHIM LAB,UA 424,F-67070 STRASBOURG,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 21期

关键词：

D O I：

10.1016/0040-4039(95)00581-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The two steps asymmetric synthesis of the enantiomerically pure (R)-4-hydroxy-4-methylcyclohex-2-en-l-one is reported in a 70% overall yield. The highly stereoselective addition of AlMe(3)/ZnBr2 to [2S,(S)R]-4,4-ethylenedioxy-2-p-tolylsulfinylcyclohexanone is the key step in this synthesis.

引用

页码：3737 / 3740

页数：4

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