PROTEIN-PHOSPHORYLATION IN NEURONAL PLASTICITY AND GENE-EXPRESSION

被引：97

作者：

SCHULMAN, H

机构：

[1] Department of Neurobiology, Stanford University School of Medicine, Stanford

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0959-4388(95)80051-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Protein kinases and phosphatases are intimately involved in several forms of synaptic plasticity. They play a critical role in the initiation of long-term potentiation and long-term depression, as well as in the induction of genes that permit long-term expression of altered synaptic states. Recent findings demonstrate a central role For the cAMP signaling pathway in the persistent phase of long-term potentiation. Genetic approaches have established that the transcription factor CREB is essential for long-term memory.

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页码：375 / 381

页数：7

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