DIGOXIN-LIKE IMMUNOREACTIVITY IN CHINESE MEDICINE

被引：18

作者：

FUSHIMI, R ^{[1
]}

KOH, T ^{[1
]}

IYAMA, S ^{[1
]}

YASUHARA, M ^{[1
]}

TACHI, J ^{[1
]}

KOHDA, K ^{[1
]}

AMINO, N ^{[1
]}

MIYAI, K ^{[1
]}

机构：

[1] OSAKA UNIV HOSP,DEPT LAB MED,OSAKA,JAPAN

来源：

THERAPEUTIC DRUG MONITORING | 1990年 / 12卷 / 03期

关键词：

Chinese medicine; Digoxin; Drug monitoring; Enzyme immunoassay;

D O I：

10.1097/00007691-199005000-00005

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Immunoreactive digoxin-like activity was observed in Chinese medicine, KYUSHIN tablet, taken popularly in Japan without prescription. The antibodies used in the assays of digoxin reacted with Chan-su, the major effective component of KYUSHIN, which contained cardiotonic steroids with similar chemical structure as digoxin. One tablet of KYUSHIN had digoxinlike immunoreactivity equivalent to 1.9, 1.5, and 72μg of digoxin measured by three different commercial kits. These different equivalences may be attributed to differences in cross-reactivity of the antibody used in the immunoassays. Two healthy volunteers took two KYUSHIN tablets three times a day, a typical dose, and digoxin-like immunoreactivity reached almost 0.4 μg/L in 0.5 day. Therapeutic drug monitoring should be interpreted carefully in patients taking Chinese medicines, many of which contain the Chan-su component. © 1990 Raven Press, Ltd., New York.

引用

页码：242 / 245

页数：4

共 18 条

[1]

BORNER K, 1978, J CLIN CHEM CLIN BIO, V16, P335

[2] DIGOXIN-SPECIFIC ANTIBODIES [J].