N-ISOPROPYL-P-[I-123]IODOAMPHETAMINE SPECT IN MELAS SYNDROME - COMPARISON WITH CT AND MR IMAGING

被引：30

作者：

SATOH, M ^{[1
]}

ISHIKAWA, N ^{[1
]}

YOSHIZAWA, T ^{[1
]}

TAKEDA, T ^{[1
]}

AKISADA, M ^{[1
]}

机构：

[1] UNIV TSUKUBA, INST CLIN MED, DEPT NEUROSURG, TSUKUBA, JAPAN

来源：

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY | 1991年 / 15卷 / 01期

关键词：

SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; ENCEPHALOMYOPATHY; BRAIN; BLOOD FLOW; MAGNETIC RESONANCE IMAGING; SPECT;

D O I：

10.1097/00004728-199101000-00010

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Regional cerebral perfusion was studied in three patients with the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome, using single photon emission computed tomography (SPECT) with N-isopropyl-p-]123I]iodoamphetamine (IMP). Accumulation of the tracer was relatively decreased in the parietooccipital regions and also in the frontotemporal regions after stroke-like episodes. However, quantitative regional cerebral blood flow (rCBF) measurement showed that rCBF was relatively well preserved even at these sites, and a hyperemic state was observed at the sites of normal accumulation. IMP SPECT may be useful in the diagnosis and assessment of the progress of the MELAS syndrome.

引用

页码：77 / 82

页数：6

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