NEUROPEPTIDE-Y IN CEREBROVASCULAR FUNCTION - COMPARISON OF MEMBRANE-POTENTIAL CHANGES AND VASOMOTOR RESPONSES EVOKED BY NPY AND OTHER VASOCONSTRICTORS IN THE GUINEA-PIG BASILAR ARTERY

被引：18

作者：

FALLGREN, B

ARLOCK, P

JANSEN, I

EDVINSSON, L

机构：

[1] UNIV LUND,DEPT INTERNAL MED,S-22185 LUND,SWEDEN

[2] UNIV LUND,DEPT ZOOPHYSIOL,S-22185 LUND,SWEDEN

[3] UNIV LUND,DEPT EXPTL RES,S-22185 LUND,SWEDEN

来源：

NEUROSCIENCE LETTERS | 1990年 / 114卷 / 01期

关键词：

Calcium channel; Cerebrovascular smooth muscle; Electromechanical coupling; Membrane depolarization; Neuropeptide Y;

D O I：

10.1016/0304-3940(90)90438-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The membrane depolarization and vasomotor response evoked by NPY and other vasoconstrictors were compared in guinea pig basilar artery. Concentrations below the pD2 value of amines and PGF2α induced contractions without significant membrane depolarization, while higher agonist concentrations depolarized the membrane slightly. Potassium-induced contractions were paralleled by strong depolarization. NPY evoked a slow depolarization which correlated to vasoconstriction over a wide concentration range. The mechanism of activation did not appear to involve the endothelium. The results suggest that NPY induces prolonged cerebrovascular smooth muscle tone by evoking longlasting depolarization, at least partly in conjunction with activation of voltage-operated calcium channels. © 1990.

引用

页码：117 / 122

页数：6

共 21 条

[1] INFLUENCE OF EXTRACELLULAR CALCIUM AND CALCIUM-ANTAGONISTS ON CONTRACTIONS INDUCED BY POTASSIUM AND PROSTAGLANDIN-F 2-ALPHA IN ISOLATED CEREBRAL AND MESENTERIC-ARTERIES OF THE CAT [J].