ENTRY OF ALPHAHERPESVIRUSES INTO CELLS

被引：339

作者：

SPEAR, PG

机构：

[1] Department of Microbiology-Immunology, Northwestern University Medical School, Chicago

来源：

SEMINARS IN VIROLOGY | 1993年 / 4卷 / 03期

关键词：

HERPESVIRUS; GLYCOPROTEINS; INFECTIVITY; VIRUS RECEPTOR; HEPARAN SULFATE;

D O I：

10.1006/smvy.1993.1012

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Studies on four alphaherpesviruses (herpes simplex virus types 1 and 2, pseudorabies virus and bovine herpesvirus 1) have revealed some common features of their entry into cells. The pathway of entry can be by fusion of the virion envelope with the cell plasma membrane. Receptors for binding and entry include heparan sulphate moieties of cell surface proteoglycans and other as yet unidentified cell surface components. Related glycoproteins specified by each of the four viruses mediate the binding of virus to heparan sulphate and subsequent molecular interactions leading to the penetration of virus into the cell. © 1993 Academic Press. All rights reserved.

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页码：167 / 180

页数：14

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