GENETIC-DIFFERENCES IN THE LOCOMOTOR RESPONSE TO SINGLE AND DAILY DOSES OF PHENCYCLIDINE IN INBRED MOUSE STRAINS

Genetic differences in the locomotor stimulant effects of both single and daily administration of phencyclidine were investigated in four inbred strains of male mice A/J, C57BL/6J, C57BL/6ByJ and BALB/cByJ. Each mouse was injected i.p. once in Experiment 1, or daily for 5 or 11 days in Experiments 2, 3 and 4. Locomotor activity was assessed with an automated photoelectric system. Significant strain differences were found in the response to a single as well as repeated doses of phencyclidine. A/J mice showed the greatest initial response to phencyclidine and developed tolerance to daily phencyclidine. C57BL/6ByJ mice showed initial resistance to acute phencyclidine, but developed sensitization to daily phencyclidine. The responses of both C57BL/6J and BALB/cByJ mice to acute phencyclidine were low to moderate, and did not change significantly following daily phencyclidine. The results of this study indicate that different genetic mechanisms are involved in responses to single and daily injections of phencyclidine.