IDENTIFICATION OF NONSTEROIDAL ANTIINFLAMMATORY DRUG-INDUCED GASTRODUODENAL INJURY IN CHILDREN WITH JUVENILE RHEUMATOID-ARTHRITIS

被引：47

作者：

MULBERG, AE

LINZ, C

BERN, E

TUCKER, L

VERHAVE, M

GRAND, RJ

机构：

[1] NEW ENGLAND MED CTR, BOSTON FLOATING HOSP INFANTS & CHILDREN, DIV RHEUMATOL, BOSTON, MA 02111 USA

[2] TUFTS UNIV, SCH MED, DEPT PEDIAT, BOSTON, MA 02111 USA

来源：

JOURNAL OF PEDIATRICS | 1993年 / 122卷 / 04期

关键词：

D O I：

10.1016/S0022-3476(05)83556-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In a cohort of children with juvenile rheumatoid arthritis treated with nonsteroidal antiinflammatory drugs and referred for gastrointestinal complaints, more than 75% had gastritis, antral erosions, or ulcers. Epigastric pain strongly correlated with documented gastroduodenal injury. Therapy with ranitidine or misoprostol led to clinical improvement. Nonsteroidal antiinflammatory drugs are associated with significant gastrointestinal abnormalities in children.

引用

页码：647 / 649

页数：3

共 15 条

[1]

AGRAWAL N, 1992, Gastroenterology, V102, pA1

[2]

AGRAWAL NM, 1989, INT J CLIN PHARM RES, V9, P347

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