C-MYC AMPLIFICATION, DOUBLE MINUTES AND HOMOGENOUS STAINING REGIONS IN A CASE OF AML

被引：29

作者：

FEGAN, CD

WHITE, D

SWEENEY, M

机构：

[1] Department of Haematology, University Hospital of Wales, Cardiff

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 90卷 / 02期

关键词：

C-MYC AMPLIFICATION; DOUBLE MINUTES; AML; HOMOGENOUS STAINING REGIONS; GCSF;

D O I：

10.1111/j.1365-2141.1995.tb05183.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

c-myc amplification is usually associated with lymphoid malignancies and Burkitt's lymphoma in particular. We present a case of AML with c-myc amplification which was associated with homogenous staining regions (hsr) and double minutes (dmin). The administration of GCSF following induction chemotherapy resulted in a marked increase in blast numbers. The GCSF was stopped and further courses of chemotherapy given, which resulted in complete remission. The patient relapsed 7 months after diagnosis and failed to go into a second remission with reinduction therapy. We conclude that c-myc amplification is a rare event in AML, but may be associated with chemotherapy resistance and a poor prognosis, are as dmins and hsr. Growth factors should be used with caution in these patients.

引用

页码：486 / 488

页数：3

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