PRODUCTION OF HYALURONAN-DEPENDENT PERICELLULAR MATRIX BY EMBRYONIC RAT GLIAL-CELLS

被引：13

作者：

DEYST, KA ^{[1
]}

TOOLE, BP ^{[1
]}

机构：

[1] TUFTS UNIV, SCH MED, DEPT ANAT & CELLULAR BIOL, BOSTON, MA 02111 USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1995年 / 88卷 / 01期

关键词：

HYALURONAN; BASIC FIBROBLAST GROWTH FACTOR; TRANSFORMING GROWTH FACTOR-BETA; EXTRACELLULAR MATRIX; EMBRYONIC GLIAL CELL;

D O I：

10.1016/0165-3806(95)00086-S

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The extracellular matrix of brain is largely composed of aggregates formed by assembly of many proteoglycan and link protein molecules along a hyaluronan polymer backbone. Some cell types construct large, highly hydrated, pericellular matrices or 'coats' from these hyaluronan-mediated aggregates. We show here that embryonic glial cells produce such hyaluronan-dependent pericellular matrices in response to addition of serum or basic fibroblast growth factor plus transforming growth factor-beta. It is proposed that such a matrix is a significant component of the extracellular milieu of the brain, especially during morphogenesis within the developing brain, and that basic fibroblast growth factor and transforming growth factor-beta regulate its production.

引用

页码：122 / 125

页数：4

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