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AGE-RELATED ACUTE DEPLETION OF CEREBRAL GLUTATHIONE BY PEROXIDATIVE STRESS

被引：15
作者：
BENZI, G
CURTI, D
MARZATICO, F
PASTORIS, O
机构：
[1] Institute of Pharmacology, University of Pavia, Pavia
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 1991年 / 29卷 / 04期
关键词：
AGING; CEREBRAL GLUTATHIONE; PEROXIDATIVE STRESS; PHOSPHATIDYLCHOLINE; PROOXIDANTS;
D O I：
10.1002/jnr.490290413
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cyclohexene-1-one and cycloheptene-1-one cause a severe age-related depletion of reduced glutathione (GSH) in the forebrain of 5- or 15- or 25-month-old rats. Chronic pretreatment with phosphatidylcholine partially inhibits the GSH depletion in old forebrains by the prooxidants tested, suggesting that in aged animals alterations in mitochondrial inner membrane phospholipid composition and/or cytochrome oxidase activity might play a role in oxygen free-radical production.
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页码：527 / 532
页数：6
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