A CONVENIENT AND EFFICIENT METHOD FOR THE PREPARATION OF 6-ACYL-2(3H)-BENZOXAZOLONES

被引：37

作者：

AICHAOUI, H

LESIEUR, D

HENICHART, JP

机构：

[1] Institut de Chimie Pharmaceutique, Lille, 59045, Rue du Professeur Laguesse

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 01期

关键词：

D O I：

10.1002/jhet.5570290131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzoxazolinone derivatives have been found to exhibit various pharmacological properties and 6-acyl-2(3H)-benzoxazolones are considered as key starting materials for the preparation of these compounds. Reported here are the optimal conditions for a regioselective acylation at the 6-position of the benzoxazolinone ring. A general method leading to the expected products in excellent yields consists in using a mixture of aluminum chloride-dimethylformamide as catalyst and acid anhydrides or chlorides as acylating agents.

引用

页码：171 / 175

页数：5

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