NERVE GROWTH-FACTOR IN ALZHEIMERS-DISEASE - DEFECTIVE RETROGRADE TRANSPORT TO NUCLEUS BASALIS

被引：178

作者：

MUFSON, EJ ^{[1
]}

CONNER, JM ^{[1
]}

KORDOWER, JH ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093

来源：

NEUROREPORT | 1995年 / 6卷 / 07期

关键词：

NERVE GROWTH FACTOR; HUMAN; RECEPTORS; TROPHIN; DISEASE; AGING; IMMUNOCYTOCHEMISTRY;

D O I：

10.1097/00001756-199505090-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NGF immunohistochemistry was combined with quantitative optical densitometry to evaluate whether retrogradely transported NGF is altered within cholinergic basal forebrain (CBF) neurons in Alzheimer's disease (AD). In normal aged humans, almost all CBF neurons stained for NGF. Although fewer in total number, remaining CBF perikarya in AD displayed diminished (32%) or undetectable NGF immunoreactivity. Based upon these data we hypothesize that there is a defect in retrograde transport of NGF in AD which may be due to a abnormal production and/or utilization of the trk receptor. This defect may be a primary event mediating the degeneration of CBF neurons in AD.

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页码：1063 / 1066

页数：4

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