INDUCTION OF TYPE-I DIABETES BY KILHAM RAT VIRUS IN DIABETES-RESISTANT BB/WOR RATS

被引：154

作者：

GUBERSKI, DL

THOMAS, VA

SHEK, WR

LIKE, AA

HANDLER, ES

ROSSINI, AA

WALLACE, JE

WELSH, RM

机构：

[1] UNIV MASSACHUSETTS, MED CTR, DEPT PATHOL, WORCESTER, MA 01655 USA

[2] UNIV MASSACHUSETTS, MED CTR, DEPT MED, WORCESTER, MA 01655 USA

[3] CHARLES RIVER LAB, WILMINGTON, MA 01887 USA

来源：

SCIENCE | 1991年 / 254卷 / 5034期

关键词：

D O I：

10.1126/science.1658938

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type I diabetes mellitus is an autoimmune disease resulting from the interaction of genetic and environmental factors. A virus that was identified serologically as Kilham's rat virus (KRV) was isolated from a spontaneously diabetic rat and reproducibly induced diabetes in naive diabetes-resistant (DR) BB/Wor rats. Viral antigen was not identified in pancreatic islet cells, and beta-cell cytolysis was not observed until after the appearance of lymphocytic insulitis. KRV did not induce diabetes in major histocompatibility complex-concordant and discordant non-BB rats and did not accelerate diabetes in diabetes-prone BB/Wor rats unless the rats had been reconstituted with DR spleen cells. This model of diabetes may provide insight regarding the interagation of viruses and autoimmune disease.

引用

页码：1010 / 1013

页数：4

共 20 条

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[2]

CERRA MA, 1991, LAB ROBOTICS AUTOMAT, V2, P119

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