REACTION OF CYANOEPOXIDES WITH 2-MERCAPTOBENZIMIDAZOLE AND 2-AMINOTHIAZOLINE AND BIOLOGICAL ASSESSMENT OF PRODUCTS FORMED

被引：22

作者：

JAGUELIN, S

ROBERT, A

GAYRAL, P

机构：

[1] UNIV PARIS 11,FAC PHARM,PARASITOL LAB,F-92290 CHATENAY MALABRY,FRANCE

[2] UNIV RENNES 1,CNRS,UA 704,RECH CHIM STRUCT GRP,F-35042 RENNES,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 01期

关键词：

DICYANO EPOXIDES; 2,3-DIHYDROBENZIMIDAZO[2,1-B]THIAZOLES; ANTIPARASITICAL PROPERTIES;

D O I：

10.1016/0223-5234(91)90212-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The two carbons of the epoxide ring of the gem-dicyano epoxides and alpha-cyano alpha-ester epoxides act as electrophilic centers when these compounds are reacted with 2-mercaptobenzimidazole. The reaction leads to 2,3-dihydrobenzimidazo[2,1-b]thiazoles. However, such a reactivity of the epoxides is not observed during their reaction with 2-aminothiazoline. Some of the synthetized compounds showed anthelminthic properties.

引用

页码：51 / 57

页数：7

共 22 条

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