CYTOGENETICS OF 3 CASES OF ANLL M2 AND M4 - INVOLVEMENT OF CHROMOSOMAL REGION 8Q22 IN ALL 3 BUT 21Q22 IN ONLY ONE

被引：4

作者：

TUERLINGS, J ^{[1
]}

NOORDHOEK, L ^{[1
]}

BOSGABOUWER, A ^{[1
]}

MUIS, N ^{[1
]}

DEJONG, B ^{[1
]}

机构：

[1] UNIV HOSP GRONINGEN,DEPT PEDIAT,DIV HEMATOL & ONCOL,GRONINGEN,NETHERLANDS

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 50卷 / 01期

关键词：

D O I：

10.1016/0165-4608(90)90243-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic investigation of the bone marrow of two patients with acute nonlymphocytic leukemia (ANLL), French-American-British Cooperative group (FAB) classification M2, revealed a translocation (8;22)(q22.1;q13.3), without involving chromosome 21, and a variant translocation (8;21)(q22;q22). These findings, together with a del(8)(q22) found in a patient with refractory anemia, erythroblastic (RAEB)-t with progression to acute myelogenous leukemia (AML)-M4, are discussed in relation to the possible role of abnormalities of chromosomes 8 and 21 in the oncogenesis of ANLL M2 and M4. © 1990.

引用

页码：103 / 107

页数：5

共 8 条

[1] PROPOSALS FOR CLASSIFICATION OF ACUTE LEUKEMIAS [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1976, 33 (04) :451-&

[2]

GOVAERTS L, 1987, CANCER GENET CYTOGEN, V30, P319

[3]

LEBEAU MM, 1984, CANCER SURV, V3, P371

[4]

LEBEAU MM, 1986, ADV HUM GENET, V15, P1

[5] TRANSLOCATION (8-21) AND ITS VARIANTS IN ACUTE NONLYMPHOCYTIC LEUKEMIA - THE RELATIVE IMPORTANCE OF CHROMOSOME-8 AND CHROMOSOME-21 TO THE GENESIS OF THE DISEASE [J].

MINAMIHISAMATSU, M ;

ISHIHARA, T .

CANCER GENETICS AND CYTOGENETICS, 1988, 33 (02) :161-173

[6]

MITELMAN F, 1988, CATALOG CHROMOSOME A

[7]

ROWLEY JD, 1984, CANCER RES, V44, P3159

[8] A CHROMOSOMAL HYPOTHESIS OF ONCOGENESIS [J].

SANDBERG, AA .

CANCER GENETICS AND CYTOGENETICS, 1983, 8 (04) :277-285

← 1 →