ALCOHOL-WITHDRAWAL IN RATS IS ASSOCIATED WITH A MARKED FALL IN EXTRANEURONAL DOPAMINE

被引：81

作者：

ROSSETTI, ZL

MELIS, F

CARBONI, S

DIANA, M

GESSA, GL

机构：

[1] Department of Neuroscience, University of Cagliari, Cagliari

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1992年 / 16卷 / 03期

关键词：

DOPAMINE; MICRODIALYSIS; ETHANOL WITHDRAWAL; PSYCHIC DEPENDENCE;

D O I：

10.1111/j.1530-0277.1992.tb01411.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Withdrawal of rats from chronic ethanol (2-5 g/kg, every 6 hr for 6 days) resulted in withdrawal symptomatology and dramatic fall in extracellular dopamine (DA) in the ventral striatum as measured by microdialysis. The changes in DA output paralleled the withdrawal symptomatology and both phenomena were reversed by a challenge ethanol dose (5 g/kg orally). The results suggest that the decrease in DA output may be responsible for the aversive symptoms of withdrawal.

引用

页码：529 / 532

页数：4

共 20 条

[1]

[Anonymous], 1985, RAT NERVOUS SYSTEM

[2]

BORG V, 1980, CURR THER RES CLIN E, V27, P170

[3] REDUCTION OF STRIATAL DOPAMINE RELEASE DURING AN ETHANOL WITHDRAWAL SYNDROME [J].

DARDEN, JH ;

HUNT, WA .

JOURNAL OF NEUROCHEMISTRY, 1977, 29 (06) :1143-1145

[4]

DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274

[5]

EISENHOFFER G, 1991, NEUROPHARMACOLOGY, V29, P37

[6]

IMPERATO A, 1986, J PHARMACOL EXP THER, V239, P219

[7]

JAFFE J H, 1990, P522

[8]

KOOB G F, 1989, Society for Neuroscience Abstracts, V15, P60

[9]

LAL H, 1988, J PHARMACOL EXP THER, V247, P508

[10] INDUCTION OF PHYSICAL-DEPENDENCE UPON ETHANOL AND ASSOCIATED BEHAVIORAL-CHANGES IN RATS [J].

MAJCHROWICZ, E .

PSYCHOPHARMACOLOGIA, 1975, 43 (03) :245-254

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