INHIBITION OF 7,12-DIMETHYLBENZANTHRACENE-INDUCED RAT MAMMARY-TUMOR GROWTH BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

被引：86

作者：

HOLCOMB, M ^{[1
]}

SAFE, S ^{[1
]}

机构：

[1] TEXAS A&M UNIV,COLLEGE STN,TX 77843

来源：

CANCER LETTERS | 1994年 / 82卷 / 01期

关键词：

2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; RAT MAMMARY TUMORS; INHIBITION;

D O I：

10.1016/0304-3835(94)90144-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds inhibit diverse estrogen-induced responses in the rodent uterus and human breast cancer cells. The effects of a single non-toxic dose of TCDD (10 mu g/kg) on the development of mammary tumors was investigated in female Sprague-Dawley rats treated with an oral dose of 7,12-dimethylbenzanthracene (DMBA) (20 mg). In rats which developed mammary tumors, subsequent treatment with corn oil (vehicle) resulted in a 3.9-fold increase in mammary tumor volume after 21 days. In contrast, a second group of rats with mammary tumors were treated with a non-toxic dose of TCDD (10 mu g/kg) and after 21 days, the mean tumor volumes decreased from 89.7 +/- 53 mm(3) to 24.9 +/- 28.5 mm(3). Moreover, these results demonstrate the antitumorigenic activity of TCDD in female Sprague-Dawley rats.

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页码：43 / 47

页数：5

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