LINKAGE OF VANCOMYCIN AND HIGH-LEVEL GENTAMICIN RESISTANCE GENES ON THE SAME PLASMID IN A CLINICAL ISOLATE OF ENTEROCOCCUS-FAECALIS

被引：44

作者：

WOODFORD, N ^{[1
]}

JONES, BL ^{[1
]}

BACCUS, Z ^{[1
]}

LUDLAM, HA ^{[1
]}

BROWN, DFJ ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,CLIN MICROBIOL & PUBL HLTH LAB,CAMBRIDGE CB2 2QW,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 35卷 / 01期

关键词：

D O I：

10.1093/jac/35.1.179

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A transferable 55-MDa plasmid which encoded resistance to both vancomycin and high concentrations of gentamicin was identified in a clinical isolate of Enterococcus faecalis. The plasmid hybridized with probes for the vanB and aac6' aph2'' resistance genes. This is the first report of linkage of glycopeptide and high-level aminoglycoside resistance genes in an Enterococcus sp.

引用

页码：179 / 184

页数：6

共 10 条

[1] ISOLATION OF A BETA-LACTAMASE-PRODUCING, AMINOGLYCOSIDE-RESISTANT STRAIN OF ENTEROCOCCUS-FAECIUM [J].

COUDRON, PE ;

MARKOWITZ, SM ;

WONG, ES .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (05) :1125-1126

[2] THE VANB GENE OF VANCOMYCIN-RESISTANT ENTEROCOCCUS-FAECALIS V583 IS STRUCTURALLY RELATED TO GENES ENCODING D-ALA D-ALA LIGASES AND GLYCOPEPTIDE-RESISTANCE PROTEINS VANA AND VANC [J].

EVERS, S ;

SAHM, DF ;

COURVALIN, P .

GENE, 1993, 124 (01) :143-144

[3] BETA-LACTAMASE-PRODUCING ENTEROCOCCI [J].

MURRAY, BE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (11) :2355-2359

[4] THE LIFE AND TIMES OF THE ENTEROCOCCUS [J].

MURRAY, BE .

CLINICAL MICROBIOLOGY REVIEWS, 1990, 3 (01) :46-65

[5] THE VANB GENE CONFERS VARIOUS LEVELS OF SELF-TRANSFERABLE RESISTANCE TO VANCOMYCIN IN ENTEROCOCCI [J].

QUINTILIANI, R ;

EVERS, S ;

COURVALIN, P .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (05) :1220-1223

[6] A MULTIPLE-STAINING PROCEDURE FOR THE DETECTION OF DIFFERENT DNA FRAGMENTS ON A SINGLE BLOT [J].

WEST, S ;

SCHRODER, J ;

KUNZ, W .

ANALYTICAL BIOCHEMISTRY, 1990, 190 (02) :254-258

[7] HIGH-LEVEL RESISTANCE TO GENTAMICIN IN ENTEROCOCCUS-FAECIUM [J].

WOODFORD, N ;

MCNAMARA, E ;

SMYTH, E ;

GEORGE, RC .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1992, 29 (04) :395-403

[8] APPLICATION OF DNA PROBES FOR RIBOSOMAL-RNA AND VANA GENES TO INVESTIGATION OF A NOSOCOMIAL CLUSTER OF VANCOMYCIN-RESISTANT ENTEROCOCCI [J].

WOODFORD, N ;

MORRISON, D ;

JOHNSON, AP ;

BRIANT, V ;

GEORGE, RC ;

COOKSON, B .

JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (03) :653-658

[9] COMPARISON OF HIGH-LEVEL GENTAMICIN-RESISTANT ENTEROCOCCUS-FAECIUM ISOLATES FROM DIFFERENT CONTINENTS [J].

WOODFORD, N ;

MORRISON, D ;

COOKSON, B ;

GEORGE, RC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (04) :681-684

[10]

1994, COMMUNICABLE DISEASE, V4, P1

← 1 →