DOPAMINE D-1 RECEPTOR, D-2 RECEPTOR, PROENKEPHALIN-A AND SUBSTANCE-P GENE-EXPRESSION IN THE CAUDATE-NUCLEUS OF CONTROL AND SCHIZOPHRENIC TISSUE - A QUANTITATIVE CELLULAR IN-SITU HYBRIDIZATION STUDY

被引:22
作者
HARRINGTON, KA
AUGOOD, SJ
FAULL, RLM
MCKENNA, PJ
EMSON, PC
机构
[1] BABRAHAM INST,DEPT NEUROBIOL,MRC,MOLEC NEUROSCI GRP,CAMBRIDGE CB2 4AT,ENGLAND
[2] UNIV AUCKLAND,SCH MED,DEPT ANAT,AUCKLAND,NEW ZEALAND
[3] UNIV CAMBRIDGE,FULBOURNE HOSP,DEPT PSYCHIAT,CAMBRIDGE,ENGLAND
来源
MOLECULAR BRAIN RESEARCH | 1995年 / 33卷 / 02期
基金
英国医学研究理事会;
关键词
STRIATUM; NEUROLEPTIC; NEUROPEPTIDE MESSENGER-RNA;
D O I
10.1016/0169-328X(95)00169-S
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cellular expression of the mRNAs encoding the dopamine D-1 receptor, dopamine D-2 receptor and the neuropeptides enkephalin and substance P was determined in fresh frozen sections of human post-mortem caudate nucleus from control and schizophrenic brains using the technique of radioactive in situ hybridisation coupled with computer-assisted image analysis. Measurements of silver grain densities and mean cross-sectional somatic areas revealed no significant differences in the expression of any of these four gene transcripts. Further, cell count estimates revealed that each of these four mRNAs was expressed by approximately 20% of caudate cells (neurones and glia) in both control and schizophrenic tissue. These data demonstrate that the cellular expression of the dopamine D-1 and D-2 receptors and the neuropeptides enkephalin and substance P mRNAs are stable post mortem and that the relative cellular abundance of these mRNAs is not altered in the caudate nucleus of schizophrenic brains when compared to controls. These findings draw into focus the possible sites of action of clinically prescribed neuroleptics and suggest that chronic neuroleptic treatment of patients displaying negative schizophrenic symptoms may 're-set' an underlying neurochemical imbalance within the caudate nucleus.
引用
收藏
页码:333 / 342
页数:10
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