RATIONAL APPROACH TO DEVELOPMENT OF ANTIVIRAL CHEMOTHERAPY - ALTERNATIVE SUBSTRATES OF HERPES-SIMPLEX VIRUS TYPE-1 (HSV-1) AND TYPE-2 (HSV-2) THYMIDINE KINASE (TK)

被引：70

作者：

CHENG, YC ^{[1
]}

机构：

[1] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,GRACE CANC DRUG CTR,DEPT EXPTL THERAPEUT,BUFFALO,NY 14263

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 1977年 / 284卷 / MAR4期

关键词：

D O I：

10.1111/j.1749-6632.1977.tb21992.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：594 / 598

页数：5

共 12 条

[1] ANTIVIRAL ACTION AND CELLULAR TOXICITY OF 4 THYMIDINE ANALOGS - 5-ETHYL-DEOXYURIDINE, 5-VINYL-DEOXYURIDINE, 5-PROPYL-DEOXYURIDINE, AND 5-ALLYL-2'-DEOXYURIDINE [J].

CHENG, YC ;

DOMIN, BA ;

SHARMA, RA ;

BOBEK, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (01) :119-122

[2]

CHENG YC, 1976, J BIOL CHEM, V251, P2605

[3]

CHENG YC, IN PRESS

[4] VIRUS TYPE-SPECIFIC THYMIDINE KINASE IN CELLS BIOCHEMICALLY TRANSFORMED BY HERPES-SIMPLEX VIRUS TYPES 1 AND 2 [J].

DAVIS, DB ;

MUNYON, W ;

BUCHSBAU.R ;

CHAWDA, R .

JOURNAL OF VIROLOGY, 1974, 13 (01) :140-145

[5] MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY [J].

DUBBS, DR ;

KIT, S .

VIROLOGY, 1964, 22 (04) :493-&

[6] DISTINCTIVE PROPERTIES OF THYMIDINE KINASE ISOENZYMES INDUCED BY HUMAN AND AVIAN HERPESVIRUSES [J].

KIT, S ;

LEUNG, WC ;

JORGENSEN, GN ;

DUBBS, DR .

INTERNATIONAL JOURNAL OF CANCER, 1974, 14 (05) :598-610

[7] GEL-ELECTROPHORESIS AND ISOELECTRIC FOCUSING OF MITOCHONDRIAL AND VIRAL-INDUCED THYMIDINE KINASES [J].

KIT, S ;

LEUNG, WC ;

TRKULA, D ;

JORGENSEN, G .

INTERNATIONAL JOURNAL OF CANCER, 1974, 13 (02) :203-218

[8] HELA CELLS RESISTANT TO BROMODEOXYURIDINE AND DEFICIENT IN THYMIDINE KINASE ACTIVITY [J].

KIT, S ;

DUBBS, DR ;

FREARSON, PM .

INTERNATIONAL JOURNAL OF CANCER, 1966, 1 (01) :19-&

[9]

KOWAL EP, 1975, FED P, V34, P2733

[10]

LEE LS, 1976, J BIOL CHEM, V251, P2600

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