COGNITIVE EVENT-RELATED POTENTIALS AND REACTION-TIME IN PRESENILE SUBJECTS WITH INITIAL MILD COGNITIVE DECLINE OR PROBABLE ALZHEIMER-TYPE DEMENTIA

被引：17

作者：

ZAPPOLI, R

VERSARI, A

ARNETOLI, G

PAGANINI, M

NENCIONI, C

ROMA, V

BATTAGLIA, A

MANIERO, A

ARDIA, A

机构：

[1] Seconda Clinica Neurologica, Università di Firenze, Franze

[2] Divisione Medica 'Farmitalia-Carlo Erba', Milano

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1990年 / 11卷 / 02期

关键词：

Contingent negative variation; presenile Alzheimer dementia; presenile cognitive decline; RT;

D O I：

10.1007/BF02335555

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The so-called contingent negative variation (CNV) is a slow brain potential representing a complex of variously overlapped "endogenous" components of behavior related to different reasonably well-known neurocognitive processes. CNV complex evoked with a standard paradigm (S1-2 sec-S2-motor response) and reaction time (RT) to imperative signal (S2) were recorded and measured in 11 patients with initial presenile idiopathic cognitive decline (PICD), 8 with presenile Alzheimer-type dementia (PAD) and 10 healthy age-matched controls. Significant group differences were obtained for measures of some CNV components, particularly of the late pre-S2 CNV. No significant CNV activity, very prolonged RTs and sometimes characteristic post-imperative negative variation (PINV) were observed in the majority of patients with PAD. These results suggest that CNV complex and RT changes similar to those observed in our patients may constitute a valuable clue for the study of pathophysiological brain functioning in the early stages of presenile idiopathic mental deterioration. © 1990 Masson Italia periodici s.r.l.

引用

页码：113 / 130

页数：18

共 64 条

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