IOCHROMOLIDE - A NEW ACETYLATED WITHANOLIDE FROM IOCHROMA-COCCINEUM

被引：20

作者：

ALFONSO, D ^{[1
]}

KAPETANIDIS, I ^{[1
]}

BERNARDINELLI, G ^{[1
]}

机构：

[1] UNIV GENEVA, CRISTALLOG LAB, CH-1211 GENEVA 4, SWITZERLAND

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 06期

关键词：

D O I：

10.1021/np50078a013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The phytochemical investigation of Iochroma coccineum (Solanaceae) afforded three withanolides: withaferine A [1], withacnistine [2], and a new compound, the (17R,20S,22R)-4-beta-hydroxy-1-oxo-5-beta,6-beta-epoxy-16-alpha-acetoxywitha-2,24-dienolide, which we called isochromolide [3]. The structure of 3 was deduced on the basis of nmr and mass spectral comparison with 1 and 2 and definitively established by X-ray crystallography.

引用

页码：1576 / 1582

页数：7

共 19 条

[1]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[2]

CHRISTEN P, 1989, PHARM ZEIT, V5, P129

[3] GENERAL DEFINITION OF RING PUCKERING COORDINATES [J].

CREMER, D ;

POPLE, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (06) :1354-1358

[4]

Glotter E., 1978, BIOORG CHEM, V2, P57

[5] C-13 NMR-SPECTROSCOPY OF THE WITHANOLIDES AND OTHER HIGHLY OXYGENATED C28 STEROIDS [J].

GOTTLIEB, HE ;

KIRSON, I .

ORGANIC MAGNETIC RESONANCE, 1981, 16 (01) :20-25

[6]

HALL SR, 1990, XTAL 3 0 USERS MANUA

[7] DETECTION AND ANALYSIS OF EPOXIDES WITH 4-(PARA-NITROBENZYL)-PYRIDINE [J].

HAMMOCK, LG ;

HAMMOCK, BD ;

CASIDA, JE .

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1974, 12 (06) :759-764

[8] CONSTITUENTS OF WITHANIA-SOMINFERA DUN .11. STRUCTURE OF 3 NEW WITHANOLIDES [J].

KIRSON, I ;

GLOTTER, E ;

ABRAHAM, A ;

LAVIE, D .

TETRAHEDRON, 1970, 26 (09) :2209-&

[9] TUMOR INHIBITORS .39. ACTIVE PRINCIPLES OF ACNISTUS ARBORESCENS . ISOLATION AND STRUCTURAL AND SPECTRAL STUDIES OF WITHAFERIN A AND WITHACNISTIN [J].

KUPCHAN, SM ;

ANDERSON, WK ;

BOLLINGER, P ;

DOSKOTCH, RW ;

SMITH, RM ;

RENAULD, JAS ;

SCHNOES, HK ;

BURLINGAME, AL ;

SMITH, DH .

JOURNAL OF ORGANIC CHEMISTRY, 1969, 34 (12) :3858-+

[10]

LAVIE D, 1968, ISRAEL J CHEM, V6, P671, DOI 10.1002/ijch.196800085

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