A MORPHOLOGICAL BIOSENSOR FOR MAMMALIAN-CELLS

被引：617

作者：

GIAEVER, I ^{[1
]}

KEESE, CR ^{[1
]}

机构：

[1] RENSSELAER POLYTECH INST,DEPT BIOL,TROY,NY 12180

来源：

NATURE | 1993年 / 366卷 / 6455期

关键词：

D O I：

10.1038/366591a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An electrical biosensor is described that can continuously track morphological changes of adherent cells providing quantitative data from both sparse and confluent cultures. The method is capable of detecting vertical motion of cells of the order of 1 nm, much below the resolution of an optical microscope.

引用

页码：591 / 592

页数：2

共 11 条

[1] MONITORING ELECTROPERMEABILIZATION IN THE PLASMA-MEMBRANE OF ADHERENT MAMMALIAN-CELLS
GHOSH, PM
KEESE, CR
GIAEVER, I
[J]. BIOPHYSICAL JOURNAL, 1993, 64 (05) : 1602 - 1609
[2] FRACTAL MOTION OF MAMMALIAN-CELLS
GIAEVER, I
KEESE, CR
[J]. PHYSICA D, 1989, 38 (1-3): : 128 - 133
[3] MONITORING FIBROBLAST BEHAVIOR IN TISSUE-CULTURE WITH AN APPLIED ELECTRIC-FIELD
GIAEVER, I
KEESE, CR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (12): : 3761 - 3764
[4] USE OF ELECTRIC-FIELDS TO MONITOR THE DYNAMIC ASPECT OF CELL BEHAVIOR IN TISSUE-CULTURE
GIAEVER, I
KEESE, CR
[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1986, 33 (02) : 242 - 247
[5] MICROMOTION OF MAMMALIAN-CELLS MEASURED ELECTRICALLY
GIAEVER, I
KEESE, CR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) : 7896 - 7900
[6] GIAEVER I, 1992, CHEMTECH, P116
[7] KEESE CR, 1990, IEEE P BIOMED ENG, V12, P500
[8] MEASUREMENT OF MACROPHAGE ADHERENCE AND SPREADING WITH WEAK ELECTRIC-FIELDS
KOWOLENKO, M
KEESE, CR
LAWRENCE, DA
GIAEVER, I
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1990, 127 (01) : 71 - 77
[9] MONITORING MOTION OF CONFLUENT CELLS IN TISSUE-CULTURE
LO, CM
KEESE, CR
GIAEVER, I
[J]. EXPERIMENTAL CELL RESEARCH, 1993, 204 (01) : 102 - 109
[10] MITRA P, 1991, BIOTECHNIQUES, V11, P504

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