ENHANCED SUSCEPTIBILITY OF CHOLESTERYL SULFATE-ENRICHED LOW-DENSITY LIPOPROTEINS TO COPPER-MEDIATED OXIDATION

被引：6

作者：

BLACHE, D ^{[1
]}

RODRIGUEZ, C ^{[1
]}

DAVIGNON, J ^{[1
]}

机构：

[1] INST RECH CLIN MONTREAL,DEPT RECH LIPIDES & ATHEROSCLEROSE,MONTREAL,PQ H2W 1R7,CANADA

来源：

FEBS LETTERS | 1995年 / 362卷 / 02期

基金：

英国医学研究理事会;

关键词：

CHOLESTERYL SULFATE; OXIDIZED LDL; OXIDATION; COPPER;

D O I：

10.1016/0014-5793(95)00246-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholesteryl sulfate (CS) is a minor component of cell membranes, also present in lipoproteins, and its exact function is unknown, Since oxidation of low density lipoproteins (LDL) is thought to be an important determinant of atherogenesis, me investigated the influence of CS enrichment on copper-mediated oxidation of LDL. CS was found to act as a pro-oxidant, as measured by lipid oxidation parameters, The results also suggest that these effects were dependent on the sulfate group since pure cholesterol or cholesteryl acetate did not promote Cu2+-mediated oxidation, Our findings imply that CS may affect the oxidizability and hence the potential atherogenicity of LDL.

引用

页码：197 / 200

页数：4

共 26 条

[1] INCREASED CHOLESTEROL SULFATE IN PLASMA AND RED-BLOOD-CELL MEMBRANES OF STEROID SULFATASE DEFICIENT PATIENTS [J].

BERGNER, EA ;

SHAPIRO, LJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 53 (01) :221-223

[2] PROOXIDANT EFFECTS OF 7-HYDROPEROXYCHOLEST-5-EN-3-BETA-OL ON THE COPPER-INITIATED OXIDATION OF LOW-DENSITY-LIPOPROTEIN [J].

BLACHE, D ;

RODRIGUEZ, C ;

DAVIGNON, J .

FEBS LETTERS, 1995, 357 (02) :135-139

[3] CHOLESTEROL SULFATE .1. OCCURRENCE AND POSSIBLE BIOLOGICAL FUNCTION AS AN AMPHIPATHIC LIPID IN MEMBRANE OF HUMAN ERYTHROCYTE [J].

BLEAU, G ;

BODLEY, FH ;

LONGPRE, J ;

CHAPDELAINE, A ;

ROBERTS, KD .

BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 352 (01) :1-9

[4]

DIEBERROTHENEDER M, 1991, J LIPID RES, V32, P1325

[5]

ELIAS PM, 1985, MODELS DERMATOLOGY, V1, P105

[6]

ELSAADANI M, 1989, J LIPID RES, V30, P627

[7] X-LINKED ICHTHYOSIS - INCREASED BLOOD CHOLESTEROL SULFATE AND ELECTROPHORETIC MOBILITY OF LOW-DENSITY LIPOPROTEIN [J].

EPSTEIN, EH ;

KRAUSS, RM ;

SHACKLETON, CHL .

SCIENCE, 1981, 214 (4521) :659-660

[8] THE ROLE OF LIPID-PEROXIDATION AND ANTIOXIDANTS IN OXIDATIVE MODIFICATION OF LDL [J].

ESTERBAUER, H ;

GEBICKI, J ;

PUHL, H ;

JURGENS, G .

FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (04) :341-390

[9]

ESTERBAUER H, 1988, FREE RADICAL RES COM, V6, P67

[10] LOW-DENSITY-LIPOPROTEIN IS SATURABLE BY PROOXIDANT COPPER [J].

GIESEG, SP ;

ESTERBAUER, H .

FEBS LETTERS, 1994, 343 (03) :188-194

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