PRODRUGS AS DRUG DELIVERY SYSTEMS .4. O-ACYLOXYMETHYL, O-ACYL AND N-ACYL SALICYLAMIDE DERIVATIVES AS POSSIBLE PRODRUGS FOR SALICYLAMIDE

被引：9

作者：

BUNDGAARD, H ^{[1
]}

KLIXBULL, U ^{[1
]}

FALCH, E ^{[1
]}

机构：

[1] ROYAL DANISH SCH PHARM,DEPT CHEM BC,DK-2100 COPENHAGEN,DENMARK

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1986年 / 30卷 / 2-3期

关键词：

D O I：

10.1016/0378-5173(86)90071-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：111 / 121

页数：11

共 25 条

[1] O-ACYLSALICYLAMIDES AS POSSIBLE PRODRUGS FOR SALICYLAMIDE .1. KINETICS AND MECHANISMS OF THEIR DEGRADATION AND REACTION WITH ENZYMES AND SODIUM BISULFITE [J].

BABHAIR, S ;

HUSSAIN, A .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1983, 13 (03) :273-&

[2]

BABHAIR S, 1979, THESIS U KENTUCKY

[3] INTESTINAL DRUG ABSORPTION AND METABOLISM .1. COMPARISON OF METHODS AND MODELS TO STUDY PHYSIOLOGICAL FACTORS OF IN-VITRO AND IN-VIVO INTESTINAL ABSORPTION [J].

BARR, WH ;

RIEGELMA.S .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1970, 59 (02) :154-&

[4] INTRAMOLECULAR PARTICIPATION OF AMIDE GROUP IN ESTER HYDROLYSIS [J].

BEHME, MT ;

CORDES, EH .

JOURNAL OF ORGANIC CHEMISTRY, 1964, 29 (05) :1255-&

[5] A CONVENIENT SYNTHESIS OF (ACYLOXY)ALKYL ALPHA-ETHERS OF PHENOLS [J].

BODOR, N ;

SLOAN, KB ;

KAMINSKI, JJ ;

SHIH, C ;

POGANY, S .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (26) :5280-5284

[6] PRODRUGS AS DRUG DELIVERY SYSTEMS .43. O-ACYLOXYMETHYL SALICYLAMIDE N-MANNICH BASES AS DOUBLE PRODRUG FORMS FOR AMINES [J].

BUNDGAARD, H ;

KLIXBULL, U ;

FALCH, E .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 29 (01) :19-28

[7]

CHARTON M, 1977, DESIGN BIOPHARMACEUT, P228

[8] 1ST-PASS ELIMINATION OF SALICYLAMIDE IN MAN FOLLOWING ORAL AND RECTAL ADMINISTRATION [J].

DEBOER, AG ;

BREIMER, DD ;

GUBBENSSTIBBE, JM ;

BOSMA, A .

BIOPHARMACEUTICS & DRUG DISPOSITION, 1983, 4 (04) :321-330

[9] ACYLAL HYDROLYSIS - HYDROLYSIS OF 3-(PARA-NITROPHENOXY)PHTHALIDE, ALPHA-ACETOXYBENZYL PARA-NITROPHENYL ETHER, AND 3-(PARA-SUBSTITUTED THIOPHENYL) PHTHALIDES [J].

FIFE, TH ;

DE, NC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (19) :6158-6165

[10]

FLECKENSTEIN L, 1976, CLIN PHARMACOL THER, V19, P451

← 1 2 3 →