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RECEPTOR-MEDIATED CALCIUM ENTRY

被引：137
作者：
RINK, TJ [1 ]
机构：
[1] PHYSIOL LAB, CAMBRIDGE CB2 3EG, ENGLAND
来源：
FEBS LETTERS | 1990年 / 268卷 / 02期
关键词：
Ca[!sup]2+[!/sup; Endothelium; Fura-2; Mn[!sup]2+[!/sup; Patch-clamp; Platelet;
D O I：
10.1016/0014-5793(90)81290-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Occupation of membrane receptors can evoke calcium signals by causing depolarisation and activating voltage-operated calcium channels, by triggering internal release, or by stimulating calcium influx processes not gated by membrane potential, receptor-mediated calcium entry, RCME. This brief review considers different possible coupling mechanisms and the proposal that entry can occur from external medium to intracellular store, by-passing the cytosol, and regulated by the state of filling of the store. Recent studies using Mn2+ as a probe for RCME are outlined, as are some new electrophysiologic measurements with human platelets and investigations of a novel blocker of RMCE, SK&F 96365. © 1990.
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页码：381 / 385
页数：5
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