THE AMINO-ACID-SEQUENCE OF A NOVEL INHIBITOR OF CATHEPSIN-D FROM POTATO

被引:62
作者
RITONJA, A [1 ]
KRIZAJ, I [1 ]
MESKO, P [1 ]
KOPITAR, M [1 ]
LUCOVNIK, P [1 ]
STRUKELJ, B [1 ]
PUNGERCAR, J [1 ]
BUTTLE, DJ [1 ]
BARRETT, AJ [1 ]
TURK, V [1 ]
机构
[1] STRANGEWAYS RES LAB, DEPT BIOCHEM, CAMBRIDGE CB1 4RN, ENGLAND
关键词
Amino acid sequence; Aspartic proteinase inhibitor; Cathepsin D;
D O I
10.1016/0014-5793(90)80275-N
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The amino acid sequence of a cathepsin D inhibitor isolated from potato is described. It was determined by analysis of peptides generated by use of the glycine-specific proteinase PPIV. The order of the peptides was established by examination of tryptic peptides derived from the two cyanogen bromide peptides. The inhibitor comprises 187 amino acid residues, and has a calculated Mr of 20 450. © 1990.
引用
收藏
页码:13 / 15
页数:3
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