EXTENSION OF THE LOO-RIEGELMAN METHOD TO PHARMACOKINETIC DATA AT STEADY-STATE

被引：1

作者：

NUESCH, EA

机构：

[1] Biostatistics Department, Clinical Research, Sandoz Pharma Ltd., Basle

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 01期

关键词：

Absorption; Bioavailability; Loo-Riegelman method; Pharmacokinetics; Steady state;

D O I：

10.1007/BF02657058

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The method of Loo and Riegelman is often used to calculate the relative amount absorbed as a function of time from plasma concentration data which follow a two-compartment open model. The method, however, is applicable only to single-dose data, whereas there is some-times interest in the absorption-time profile at steady state after multiple doses. The method is modified here so that it can be applied to steady-state data and its use with a practical example is illustrated. © 1990 Springer-Vertag.

引用

页码：55 / 57

页数：3