BIOLOGICALLY-ACTIVE GAMMA-LACTONES AND METHYLKETOALKENES FROM LINDERA-BENZOIN

被引：49

作者：

ANDERSON, JE ^{[1
]}

MA, W ^{[1
]}

SMITH, DL ^{[1
]}

CHANG, CJ ^{[1
]}

MCLAUGHLIN, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 01期

关键词：

D O I：

10.1021/np50079a011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Brine shrimp lethality-directed fractionation of the 95% EtOH extract of ripe berries from Lindera benzoin led to the isolation of three new C21 alkane-alkene gamma-lactones designated isolinderanolide {4}, isolinderenolide {5}, and linderanolide {10} as well as the known series of C-17 and C-19 obtusilactones (isoobtusilactone A {6}, obtusilactone A {7}, isoobtusilactone {8}, and obtusilactone {9}) previously isolated from Lindera obtusiloba. The novel (6Z, 9Z, 12Z)-pentadecatrien-2-one {2}, the known (6Z,9Z)-pentadecadien-2-one {1}, and the known (+)-(Z)-nerolidol {3} were also isolated as bioactive compounds. The structural elucidation and biological activities of these compounds are reported.

引用

页码：71 / 83

页数：13

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