DIARYL TELLURIDES AS INHIBITORS OF LIPID-PEROXIDATION IN BIOLOGICAL AND CHEMICAL-SYSTEMS

被引:67
作者
ANDERSSON, CM
BRATTSAND, R
HALLBERG, A
ENGMAN, L
PERSSON, J
MOLDEUS, P
COTGREAVE, I
机构
[1] KAROLINSKA INST,INST ENVIRONM MED,DIV TOXICOL,S-17177 STOCKHOLM,SWEDEN
[2] ASTRO DRACO AB,PRECLIN RES & DEV,DEPT MED CHEM & PHARMACOL 1,S-22100 LUND,SWEDEN
[3] ROYAL INST TECHNOL,DEPT ORGAN CHEM,S-10044 STOCKHOLM,SWEDEN
关键词
LIPID PEROXIDATION; MICROSOMES; HEPATOCYTES; DIARYL TELLURIDES; ANTIOXIDANTS;
D O I
10.3109/10715769409145639
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diaryl tellurides carrying electron-donating substituents in the para positions were found to efficiently inhibit peroxidation of rat hepatocytes, rat liver microsomes and a chlorobenzene solution of phosphatidylcholine. The most active compound in the microsomal assay, bis(4-dimethylaminophenyl) telluride, showed an IC50-value of 30 nM. This compound also caused a dose-dependent delay of the onset of the linear phase of microsomal peroxidation stimulated by iron/ADP/ascorbate. The peak oxidation potentials of the diaryl tellurides (0.50-1.14 V in MeCN) correlated linearly with the IC50-values in this assay, with a point of inflection around 0.85 V. In the hepatocyte system, all compounds showed similar protective activity. It is proposed that diaryl tellurides exert an antioxidative effect by deactivating both peroxides and peroxyl radicals under the formation of telluroxides. These oxides may regenerate the active divalent organotellurides upon exposure to a suitable reducing agent.
引用
收藏
页码:401 / 410
页数:10
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